It is best suited for aquariums that are 10 gallons or larger which have adequate hiding places along with ample swimming space. The aquarium should have a tight-fitting lid to prevent it from jumping out. The Orange Spotted Goby adapts well to reef aquariums, although it does pose a possible threat to small, delicate ornamental shrimp. It prefers a bed of fine sand and loose coral rubble to sift through.
It is possible for the Orange Spotted Goby to spawn successfully in an aquarium.
Its diet should consist of a variety of fresh or frozen mysis shrimp, vitamin-enriched brine shrimp, and table shrimp. Will benefit from frequent feeding.