It tends to do well in an aquarium if provided with live rock in a 10 gallon or larger aquarium. The live rock provides places to hunt and feed on small crustaceans as well as places to hide. It is not usually aggressive unless the tank mates appear to have a similar shape as it does. Its fangs are more of a defense mechanism used for biting an aggressive fish back.
The Smith's Blenny diet consists of chopped crustaceans, vitamin-enriched brine shrimp, and frozen food preparations for herbivores.